King of Thorn

マルコ・オーエン

Marco Owen is the male main character of the series. He is a fearsome-looking man with a muscular frame and many intimidating tattoos all over his body who is also an expert hacker, so much so that he was able to crack through the CIA's computers – and those of Venus Gate, something that had him arrested and incarcerated for more than half a century (during the events of the manga, he still had 60 years to serve in prison). While a prisoner he was approached by the NSA, which offered him complete parole for his crimes in exchange of his help in dealing with the Medusa affair. Becoming a de facto spy for the United States, he was sent as a patient to the gathering at Venus Gate labs, the same where all the other main characters were sent, in order to assess the objectives of the gathering, gather evidence on the mysterious Level 4 labs of the island, and also to pursue a personal vendetta against his old friend Zeus, who framed him for crimes he did not commit before vanishing.

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カスミ・イシキ

Kasumi Ishiki is the main protagonist of this story who was diagnosed by the Medusa virus along with Shizuku Ishiki (Kasumi's twin sister). 160 people out of the world were chosen to be cryogenically frozen until a cure was found and Kasumi was one of those few selected. She is devastated by the fact that Shizuku was left behind and the mere thought of leaving her to die.

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アリス

Alice Roznovski is a young Russian girl who suffered from dissociative identity disorder. Alice had an imaginary friend whom she named Laloo who had the features of a cat.

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ウォルター

キャサリン・ターナー

Katherine Turner is a young woman in her late twenties who was the worst Medusa case among the survivors, being the most infected one of them all. Since their encounter she acts in a motherly way towards Tim Laisenbach, the youngest of them being only a little boy. Before becoming infected, Katherine was an alcoholic and was prone to abuse her son Michael, until he was taken away from her and placed in foster care. This events shook her greatly and left her with bitter disgust for herself, prompting her to try to be a true mother for Tim as she wasn't for her son.

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アイヴァン・コラル・ヴェガ

Ivan Coral Vega was the Russian founder of Venus Gate, a religious cult which came to see the power of Medusa as a gift from God himself and which took Alice in after discovering her in Siberia. Though her suffering, it could be attributed to him and his religious views could have been easily labeled as senseless fanaticism, Vega was indeed left speechless and horrified by the sheer cruelty of Zeus, whose true identity and goals he was oblivious of, and during the chaotic outbreak at Level 4 he sealed himself inside his study, deep in the facility.

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ゼウス

Zeus is the main antagonist of the series. Considered to be the best hacker in the world and a closely observed subject by both NSA and CIA, and the archenemy of Marco. The two were apparently rivals in their past, until Zeus broke into the CIA mainframe and then framed Marco for the crime, escaping soon after.

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アレッサンドロ・ペッチノ

Alexandro Pecchino was an elderly white man and a politician who bought his place among those chosen to be cured, he was gruff and cowardly, always putting his well-being before that of others. He was the first one to notice that Marco Owen was a dangerous criminal by seeing his tattoos, sparking a brief but intense confrontation which fortunately ended thanks to Peter's reasoning and Kasumi's pleas. He was devoured alive by ferocious, over-sized eels while the group was traveling through an underground flooded tunnel.

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ロン・ポートマン

Ron Portman is a black man hailing from the United States. The most physically strong of the survivors, he was something of a fatalist, frequently lamenting on how hopeless the situation was and how useless struggling to survive would be. Despite his lack of optimism, he nevertheless tried to escape with his life, though he refused to enter Level 4 and was left behind, his leg injured.

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ピーター・スティーブンス

Peter Stevens was an engineer and doctor, the creator of the cold sleep capsules used by Kasumi and the other people gathered by Venus Gate. Despite his success in creating stable prototypes of the capsules, a sudden crisis of the electronics market left him without financial support, until Venus Gate expressed interest in his project and hired him and his colleagues.

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